CRVBC 2025

11th Cardiac Regeneration and Vascular Biology Conference

Island of San Servolo, Venice
30 June - 02 July 2025

Abstracts

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OR01

Preclinical

VIEW

Scavenger receptor F1 activates GRB2-MAPK axis to promote atherosclerosis

Arailym Aronova, Institute for Stroke and Dementia Research, LMU Munich, Munich, Germany

OR02

Preclinical

VIEW

Tracking inflammatory monocytes via IFN-specific signatures from peripheral blood to the atherosclerotic plaque

Lorenzo Marcone, Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy / Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy

OR03

Preclinical

VIEW

Endothelial Notch4 Activation Drives Structural Vascular Abnormalities in Cardiac Hypertrophy

Simone-Franziska Glaser, Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Germany / German Centre for Cardiovascular Research (DZHK), partner site Frankfurt Rhine-Main, Berlin, Germany / Cardiopulmonary Institute, Goethe University Frankfurt, Germany.

OR04

Preclinical

VIEW

Vegfa regulates an angiocrine signature determining neural behavior and spinal cord regeneration by titrating immune cell dynamics

Laetitia Préau, Department of Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131 Karlsruhe, Germany

OR05

Preclinical

VIEW

TIMP-1 overexpression as a novel gene therapy approach for Marfan syndrome

Marie Isabel Noormalal, Department of Internal Medicine III, University of Kiel, and German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Germany

P01

Preclinical

VIEW

AAV-mediated gene therapy in a porcine model of Duchenne Muscular Dystrophy

Ina Luksch, Klinik und Poliklinik für Innere Medizin I, University Clinic Rechts der Isar, School of Medicine and Health, Technical University of Munich / DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

P02

Preclinical

VIEW

Leveraging Asymptomatic PAD as a Model for Translational Insights into Immune Regulation and Monocyte Contributions to Collateral Artery Formation

Henry Nording, Department of Internal Medicine V (Cardiology and Angiology), University of Kiel, and German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany / DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany / Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany

P03

Preclinical

VIEW

Gene-enrichment analysis in dominant and recessive genotypes of HLHS patients

Elisa Mastantuono, First Department of Medicine, TUM Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany

P04

Preclinical

VIEW

Transcriptional Upregulation as a Potential Therapeutic Strategy for PKP2 Mutation-Related Cardiomyopathies

Solomon Kiprop Yator, TUM University Clinics, Clinic for Cardiology, Technical University of Munich

P05

Clinical

VIEW

Eccentric hypertrophy impairs outcome after TAVR

Viktoria Obermeier, Department of Internal Medicine I (Cardiology), University Hospital rechts der Isar, Technical University of Munich, Munich, Germany

P06

Preclinical

VIEW

Natural aging as a cardiovascular disease: insights from a non-human primate model

Mostafa Samak, Laboratory Animal Science Unit, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany / German Center for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany

P07

Preclinical

VIEW

FYCO1 improves cardiac remodeling in response to ischemia by amplifying autophagic flux in vivo

Frauke Senger, Department of Internal Medicine III, University Hospital Heidelberg, Germany

P08

Preclinical

VIEW

Assessing alginate biomaterials for aortic gene therapy vector delivery

Prithviraj Shetty, Department of Internal Medicine V, University of Kiel, and German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Germany

P09

Preclinical

VIEW

Vascular HDAC9 regulates pro-inflammatory responses to control neointima formation upon arterial damage

Federica Tosato, Institute for Stroke and Dementia Research, LMU Munich, Munich, Germany

P10

Preclinical

VIEW

Single-Cell and Single-Nucleus Multiomics Reveal Cardiac Endothelial Cell Heterogeneity and
Novel Pathological Processes in Pressure Overload-Induced Hypertrophy

Giulia Demenego, Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano (MI), Italy

P11

Preclinical

VIEW

Immature neutrophils in myocardial infarction: dynamics, function, and therapeutic implications.

Zoe Möller-Ramon, Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Germany / German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Germany

P12

Preclinical

VIEW

Development of a Cre-Activated AAV9 Peptide Library for Targeted Selection in Cardiac Conduction Cells

Nicola Deyerling, Department of Internal Medicine V, University Hospital Schleswig-Holstein and University of Kiel, Kiel, Germany / German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany

P13

Preclinical

VIEW

Nanoparticle Based Enhancement and Retargeting of AAV-Mediated Gene Delivery

Seyed Amir Shakouri, Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich, Germany; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance, Munich, Germany

P14

Preclinical

VIEW

The HDAC9 risk locus in chronic inflammation in atherosclerosis

Nawraa Naser, Institute for Stroke and Dementia Research (ISD), LMU Munich, Munich, Germany

P15

Preclinical

VIEW

Role of endothelial constitutive photomorphogenesis 9 (COP9) in atherosclerosis

Yue Yuan and Lea Klose, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig Maximilian University (LMU), Munich, Germany

P16

Preclinical

VIEW

A Porcine Model for Cardiac Hypertrophy Induced by Catheter-Based Aortic Stent placement

Mara Corsten, Department of Internal Medicine I, Klinikum rechts der Isar, TU Munich, Germany / Center for Innovative Medical Models; LMU Munich, Germany

P17

Preclinical

VIEW

A sympathetic nerve-driven neuroimmune crosstalk with macrophages synchronizes systemic sympathetic states to local immune programming

Christoph Gold, LMU Klinikum, Medizinische Klinik I, Munich

P18

Preclinical

VIEW

Decoding Proangiogenic Immunity in Asymptomatic PAD: A Signature of Optimal Collateral Adaptation

Maximilian Leuner, Institute of Human Genetics, Universitätsklinikum Schleswig-Holstein, University of Lübeck and University of Kiel, 23562, Lübeck, Germany / Department of Internal Medicine V (Cardiology and Angiology), University of Kiel, and German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Kiel, 24105, Germany / DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, 23562, Germany

P19

Preclinical

VIEW

Novel strategies to reactivate and trace regeneration capacity in adult cardiomyocytes

Lu Han, Max Planck Institute for heart and lung, Bad Nauheim, 61231, Germany / Cardiac Pulmonary Institute / DZHK

P20

Preclinical

VIEW

Measurement of endothelial force transduction in vivo

Ario Dastmaltschi, Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar der Technischen Universität München, München

P21

Preclinical

VIEW

Multidimensional profiling of systemic immunity unravels key roles of circulating CD4+ T cell axes in modulating infective endocarditis

Rainer Kaiser, Medizinische Klinik und Poliklinik I, University Hospital Ludwig-Maximilians University, Munich, Germany / DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany

P22

Preclinical

VIEW

Carbon dots induce remodelling of ECM: potent application for vascular damage

Yingqiu Xie, Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan

P23

Preclinical

VIEW

The dual role of TFPT in INO80-denpendent and independent pathways during heart development

Qing Yin, Group Boettger, Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany

P24

Preclinical

VIEW

LEA29Y expression affects myocardial scar formation after ischemia/reperfusion in pigs

Heinke Heymer, Department of Internal Medicine I, Klinikum rechts der Isar, TU Munich, Germany / Center for Innovative Medical Models; LMU Munich, Germany

P25

Preclinical

VIEW

Characterization of a PLN R14del pig model using cell stress markers

Eva-Maria Männer, Department of Internal Medicine I, Klinikum rechts der Isar, TU Munich, Germany

P26

Clinical

VIEW

Protected-PCI-Registry at TUM University Hospital Rechts der Isar – First results of our monocentric study on impella-protected-PCI

Sebastian Bufler, TUM Universitätsklinikum Rechts der Isar

P27

Preclinical

VIEW

Engineering miniature CRISPR-Cas proteins for gene editing in human cardiomyocytes

Jessica Kornherr, Department of Cardiology, TUM University Hospital - Klinikum rechts der Isar, Technical University of Munich / DZHK

11th Cardiac Regeneration and Vascular Biology Conference

11th Cardiac Regeneration and Vascular Biology Conference

Island of San Servolo, Venice 30 June - 02 July 2025

Abstracts

Island of San Servolo, Venice
30 June - 02 July 2025